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A trailblazing biologist grapples with her role in the biggest scientific discovery of our era: a cheap, easy way of rewriting genetic code, with nearly limitless promise and peril.
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers, and will help address the world’s hunger crisis. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences—to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans.
Writing with fellow researcher Samuel Sternberg, Doudna shares the thrilling story of her discovery, and passionately argues that enormous responsibility comes with the ability to rewrite the code of life. With CRISPR, she shows, we have effectively taken control of evolution. What will we do with this unfathomable power?
- Sales Rank: #34672 in Books
- Published on: 2017-06-13
- Released on: 2017-06-13
- Original language: English
- Dimensions: 9.00" h x 1.10" w x 6.00" l,
- Binding: Hardcover
- 304 pages
Review
“A Crack in Creation is a powerful testament to the role of curiosity and tenacity in scientific research, and also an urgent plea from the celebrated biologist whose discovery enabled us to rewrite the code of life. The future is in our hands as never before, and this book explains the stakes like no other.”
—George Lucas, filmmaker
“Urgent, riveting, and endlessly fascinating, A Crack in Creation is a journey through the past, present, and future of one of biology’s most significant discoveries. Combining deep historical perspectives, personal narrative, and scientific data, Doudna and Sternberg bring the story of CRISPR and ‘gene editing’ alive with pointed honesty and clarity. This book is destined to become an instant classic. Read it and understand its implications if you want to understand our biological future.”
—Siddhartha Mukherjee, Pulitzer Prize–winning author of The Gene and The Emperor of All Maladies
“The technology of gene editing will be the most important advance of our era, one that will create astonishing opportunities combined with frightening moral challenges. In the tradition of The Double Helix, one of the pioneers of the field describes the exciting collaborative and competitive hunt for the key breakthrough and what it portends for our future.”
—Walter Isaacson, bestselling author of Steve Jobs, Einstein, and The Innovators
“A Crack in Creation, by one of the most pioneering women in science, is both exhilarating and frightening. Jennifer Doudna and her co-author Samuel Sternberg challenge us to confront the possible dangers of gene editing, even as we embrace its incredible potential. This book is a roadmap to our future.”
—Arianna Huffington, bestselling author of Thrive and The Sleep Revolution
“Jennifer Doudna is the true pioneer who built the bridge between the basic science of CRISPR and its diverse applications in agriculture and medicine. Writing with Samuel Sternberg, she has crafted a beautifully written book with A Crack in Creation—a pure pleasure for both neophyte and expert. Now is the time to read about the revolution that could change our world.”
—George Church, Professor of Genetics at Harvard Medical School and author of Regenesis
“We are developing ever more powerful tools that allow us to change the genetic makeup not only of life around us but also of ourselves. Describing the potential benefits of these tools as well as some of the risks and ethical issues they present to society, A Crack inCreation is a scientific thriller and a gripping read, framed as a personal voyage by a brilliant scientist who played a major role in developing what is currently one of the most promising and powerful ways of editing our genomes.”
—Venki Ramakrishnan, president of the Royal Society and winner of the Nobel Prize in Chemistry
“An enthusiastic and definitely not dumbed-down account of gene manipulation that, unlike earlier methods, is precise and easy...an important book about a major scientific advance.”
—Kirkus Reviews, STARRED
“The authors describe the biological mechanisms in a way that nonspecialists can appreciate...excellent book.”
—Publishers Weekly
About the Author
JENNIFER A. DOUDNA, Ph.D. is a professor in the Chemistry and the Molecular and Cell Biology Departments at the University of California, Berkeley, investigator with the Howard Hughes Medical Institute, and researcher in the Molecular Biophysics and Integrated Bioimaging Division at the Lawrence Berkeley National Laboratory. She is internationally recognized as a leading expert on RNA-protein biochemistry, CRISPR biology, and genome engineering. She lives in the Bay Area.
SAMUEL H. STERNBERG, Ph.D., is a biochemist and author of numerous high-profile scientific publications on CRISPR technology. He presents his research to international audiences and has received the Scaringe Award and the Harold M. Weintraub Graduate Student Award, among other honors. He lives in the San Francisco Bay Area.
Most helpful customer reviews
1 of 1 people found the following review helpful.
A must-read popular science book
By Malvin
“A Crack in Creation” by Jennifer A. Doudna and Samuel H. Sternberg is simply a must-read popular science book. Professor Doudna led the research team responsible for the breakthrough gene editing technology, CRSIPR. This important book promises to stimulate informed conversation about the new, unprecedented powers of creation that have recently been placed in human hands.
The book is divided into two sections. Part I: The Tool documents the discovery process that led to CRISPR. No doubt, the author’s painstaking reconstruction of events will prove immensely valuable to students and scientists. The authors have a knack for explaining complex concepts in an accessible manner. Still, for generalists like myself, I found myself skimming through sections because the science (for my taste) trends towards the arcane.
Part II: The Task talks about the potential uses and abuses of CRISPR. The authors envision useful systemic applications including immunotherapy to fight disease, the purposeful engineering of more productive crops and livestock, and so on. Human germline applications, of course, are more problematic. The authors are sympathetic to the cause of eradicating genetic conditions but are concerned about unwise experimentation (e.g., designer babies). After reading the author’s reasoned thoughts and perspectives, I feel much better informed and engaged. There is no doubt that gene editing will be widely discussed and debated for many years to come.
I highly recommend this excellent book to everyone.
1 of 1 people found the following review helpful.
A Well Told Journey of Scientific Discovery That Equals "Microbe Hunters" and "The Double Helix"
By Ira Laefsky
Not since "Microbe Hunters" by Paul de Kruif Microbe Hunters and "The Double Helix" by Watson and Crick The Double Helix: A Personal Account of the Discovery of the Structure of DNA has the excitement of discovery in the biological sciences been expressed and made vivid for lay readers in the way that Douda and Sternberg's account of their research into Bacterial Immunological Systems and application of CRISPR/CAS9 for Gene Editing displays. This easily understood scientific autobiography documents much of the research that led to one of the most important discoveries in molecular biology and genetic engineering in recent decades. The clear prose and simple diagrams which document CRISPR and its mechanisms make clear and make exciting this journey of scientific discovery,
Highly Recommended
0 of 1 people found the following review helpful.
The advent of Khan Noonien Singh is nigh : jaw dropping technology
By Eliot Rosewater
A CRACK IN CREATION is written in the voice of the main author, Jennifer A. Doudna, who is one of the lead researchers into the CRISPR gene editing techniques. The co-author, Samuel H. Sternberg, also a leading expert in the field, is literarily in the background.
Though gene manipulation and the editing of DNA is not relatively new technology, the CRISPR (Clustered regularly interspaced short palindromic repeats) techniques are notable for being inexpensive and incredibly accurate at editing genomes. If you Google "CRISPR" you will retrieve ad based links to companies that are already selling inexpensive CRISPR editing kits and customized sgRNA (single guide RNA) which is used to make specific modifications.
The first part of the book, "The Tool," is a fairly dry explanation of the development and function of CRISPR. If anything, the author may suffer from being too familiar with the topic leading to this being the least accessible part of the book. Scientific dilettantes (like myself) should soldier through the array of genetic terminology and themes, but the reward is a deeper understanding of the actual technology. Dr. Doudna could benefit from expanding on the personal aspects and interactions with other players in the field. There are hints of a deeper and more fascinating human story in this first part.
It is the second part of the book, "The Task," that the authors use to explore the potential of CRISPR, and the related ethical issues that, in the past, were more theoretical. Earlier genome editing techniques have required more extensive laboratory infrastructure and were thus self-limiting in their impacts (though the impact of genetic manipulation is not trifling). Dr. Doudna and Dr. Sternberg emphasize the ethical questions particularly surrounding the editing of the germline, i.e., human embryos. Humans have always manipulated their environment, and sometimes to our own detriment, e.g., global climate change. With CRISPR, the authors posit we have the atomic bomb of gene editing tools, and that we should approach ethical concerns about research in the same manner. As with nuclear energy, the potential benefits are astounding. As with nuclear energy, the potential threat is also astounding.
The title of this review, "The advent of Khan Noonien Singh," refers to the iconic character from the Star Trek universe, who is the leader of a genetically manipulated crew of super humans. The authors have convinced me that creation of designer humans, such as Khan, is no longer just possible but probable. In one section of the book they discuss being approached by a biotech firm for assistance in creating embryos that are designed to avoid known genetic diseases. Though the proposal is prophylactic in nature, they make the case that it is obvious that editing the genome for desirable traits (strength, intelligence, gender) involves the same inexpensive CRISPR techniques.
The call in this book is for more involvement by the world community beyond the sphere of the scientific experts. There are no easy answers, and the second part of the book involves raising the questions and the importance of involving a wider universe of stakeholders. Stakeholders = human beings.
This book easily stands alongside The Double Helix: A Personal Account of the Discovery of the Structure of DNA by James Watson.
The NOTES section at the end is one of the best I've seen. Not only does it give the page number of the footnote and citation to more in depth information, it also includes a snippet of the phrase which originally references the note. E.g., Page 46. . . . the institute had over a thousand employees producing tons of phages per year: Carl Zimmer, A Planet of Viruses (Chicago : University of Chicago Press, 2011).
This is a must read. Period.
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